Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy

@inproceedings{Warhaut2017LigandmodulatedFO,
  title={Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy},
  author={Sven Warhaut and Klara Rebecca Mertinkus and Philipp H{\"o}llthaler and Boris F{\"u}rtig and Mike Heilemann and Martin Hengesbach and Harald Schwalbe},
  booktitle={Nucleic acids research},
  year={2017}
}
The full-length translation-regulating add adenine riboswitch (Asw) from Vibrio vulnificus has a more complex conformational space than its isolated aptamer domain. In addition to the predicted apo (apoA) and holo conformation that feature the conserved three-way junctional purine riboswitch aptamer, it adopts a second apo (apoB) conformation with a fundamentally different secondary structure. Here, we characterized the ligand-dependent conformational dynamics of the full-length add Asw by NMR… CONTINUE READING
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