Ligand-inducible interaction of the DRIP/TRAP coactivator complex with retinoid receptors in retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.

@article{Shao2000LigandinducibleIO,
  title={Ligand-inducible interaction of the DRIP/TRAP coactivator complex with retinoid receptors in retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells.},
  author={Wenlin Shao and Angelika Rosenauer and Karlheinz Mann and C P Chang and Christophe Rachez and Leonard P. Freedman and Wilson H. Miller},
  journal={Blood},
  year={2000},
  volume={96 6},
  pages={2233-9}
}
Retinoic acid (RA) signaling is mediated by its nuclear receptors RXR and RAR, which bind to their cognate response elements as a heterodimer, RXR/RAR, and act in concert with coregulatory factors to regulate gene transcription on ligand binding. To identify specific cofactors that interact with the RXR/RAR heterodimer in acute promyelocytic leukemia (APL) cells, a double cistronic construct was used that allowed coexpression of the RXR LBD (ligand binding domain) with the RAR LBD as an… CONTINUE READING