Ligand-induced peroxisome proliferator-activated receptor alpha conformational change.

  title={Ligand-induced peroxisome proliferator-activated receptor alpha conformational change.},
  author={Paul Dowell and Valerie J Peterson and T. Mark Zabriskie and Mark E Leid},
  journal={The Journal of biological chemistry},
  volume={272 3},
Structurally diverse peroxisome proliferators and related compounds that have been demonstrated to induce the ligand-dependent transcriptional activation function of mouse peroxisome proliferator-activated receptor alpha (mPPARalpha) in transfection experiments were tested for the ability to induce conformational changes within mPPARalpha in vitro. WY-14,643, 5,8,11,14-eicosatetraynoic acid, LY-171883, and clofibric acid all directly induced mPPARalpha conformational changes as evidenced by a… CONTINUE READING


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