Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity.

@article{Cawston2012LigandinducedIO,
  title={Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity.},
  author={Erin E Cawston and Kaleeckal G. Harikumar and Laurence J. Miller},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={302 3},
  pages={
          C615-27
        }
}
Receptor ligands, identified as antagonists, based on the absence of stimulation of signaling, can rarely stimulate receptor internalization. d-Tyr-Gly-[(Nle(28,31),d-Trp(30))CCK-26-32]-2-phenylethyl ester (d-Trp-OPE) is such a ligand that binds to the cholecystokinin (CCK) receptor and stimulates internalization. Here, the molecular basis of this trafficking event is explored, with the assumption that ligand binding initiates conformational change, exposing an epitope to direct endocytosis… CONTINUE READING

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