Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome.

@article{Bronfman2003LigandinducedIO,
  title={Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome.},
  author={Francisca C. Bronfman and Marianna Tcherpakov and Thomas M. Jovin and Mike Fainzilber},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 8},
  pages={
          3209-20
        }
}
The nerve growth factor (NGF) family of neurotrophins binds two classes of cell-surface receptors, trk receptor tyrosine kinases and the shared p75 receptor. Rapid internalization and retrograde trafficking of neurotrophin-trk complexes have been demonstrated in a number of systems and are thought to transmit trophic signals from terminals to neuronal cell bodies. In contrast, the internalization and trafficking of neurotrophin-p75 complexes are not well understood. In this study, we used… CONTINUE READING

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