Ligand-induced growth cone collapse: amplification and blockade by variant GAP-43 peptides.

  title={Ligand-induced growth cone collapse: amplification and blockade by variant GAP-43 peptides.},
  author={Michihiro Igarashi and Wei W. Li and Y Sudo and Mark C Fishman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={15 8},
Growth cones are powerful amplifiers for signals from the microenvironment. Their collapse can be triggered by cell surface components of myelin and brain membranes, as well as by soluble ligands, including neurotransmitters. GAP-43 is a protein concentrated on the inner surface of the growth cone membrane. Assayed in isolation, it interacts with the heterotrimeric protein, G(o), and in oocytes it amplifies the effects of ligand-triggered G protein activation. We wished to examine whether GAP… CONTINUE READING


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