Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis.

@article{Clayton2005LigandinducedDT,
  title={Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis.},
  author={Andrew H. A. Clayton and Francesca Walker and Suzanne Orchard and Christine Henderson and Dominik Fuchs and Julie Rothacker and Edouard C Nice and Antony W. Burgess},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 34},
  pages={30392-9}
}
The epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family of receptors. For many years it has been believed that receptor activation occurs via a monomer-dimer transition that is associated with a conformational change to activate the kinase. However, little is known about the quaternary state of the receptor at normal levels of expression (<10(5) receptors/cell). We employed multidimensional microscopy techniques to gain insight into the state of association of… CONTINUE READING

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