Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor.

@article{Quast1978LigandinducedCC,
  title={Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor.},
  author={Ulrich Quast and Michael I. Schimerlik and T Lee and T L Witzemann and Steven G. Blanchard and Michael A. Raftery},
  journal={Biochemistry},
  year={1978},
  volume={17 12},
  pages={2405-14}
}
A time-dependent increase in ligand affinity has been studied in cholinergic ligand binding to Torpedocalifornica acetylcholine receptor by inhibition of the kinetics of of [125I]-alpha-bungarotoxin-receptor complex formation. The conversion of the acetylcholine receptor from low to high affinity form was induced by both agonists and antagonists of acetylcholine and was reversible upon removal of the ligand. The slow ligand induced affinity change in vitro resembled electrophysiological… CONTINUE READING

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