Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.

@article{Leid1994LigandinducedAO,
  title={Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.},
  author={Mark E Leid},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 19},
  pages={
          14175-81
        }
}
  • Mark E Leid
  • Published in The Journal of biological chemistry 1994
Ligand-induced structural alterations of retinoid X receptor (RXR) appear to facilitate receptor homodimerization, to enhance DNA binding of RXR homodimeric complexes, and to dictate the transcriptional activation properties of RXR complexes bound to response elements located in the promoter region of 9-cis-retinoic acid responsive genes. The technique of limited proteolysis was used to address 9-cis-retinoic acid-induced RXR conformational change and to identify receptor region(s) which… CONTINUE READING

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