Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor.

@article{Chang2007LigandindependentRO,
  title={Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor.},
  author={Xiaoqing Chang and Yunxia Fan and Saikumar Karyala and Sandy J Schwemberger and Craig R. Tomlinson and Maureen A. Sartor and Alvaro Puga},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 17},
  pages={6127-39}
}
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxic effects of its xenobiotic ligands and acts as an environmental checkpoint during the cell cycle. We expressed stably integrated, Tet-Off-regulated AHR variants in fibroblasts from AHR-null mice to further investigate the AHR role in cell cycle regulation. Ahr+/+ fibroblasts proliferated significantly faster than Ahr-/- fibroblasts did, and exposure to a prototypical AHR ligand or deletion of… CONTINUE READING

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