Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection.

@article{Alter2008LigandindependentEO,
  title={Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection.},
  author={Galit Alter and Suzannah Rihn and Hendrik Streeck and Nickolas Teigen and Alicja Piechocka-Trocha and Kristin L Moss and Kristen E. Cohen and Angela Meier and Florencia Pereyra and Bruce M. Walker and Marcus Altfeld},
  journal={Journal of virology},
  year={2008},
  volume={82 19},
  pages={9668-77}
}
Virus-specific CD8(+) T cells play a central role in the control of viral infections, including human immunodeficiency virus type 1 (HIV-1) infection. However, despite the presence of strong and broad HIV-specific CD8(+) T-cell responses in chronic HIV-1 infection, these cells progressively lose critical effector functions and fail to clear the infection. Mounting evidence suggests that the upregulation of several inhibitory regulatory receptors on the surface of CD8(+) T cells during HIV-1… CONTINUE READING

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