Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling.

@article{Yu2002LigandindependentDF,
  title={Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling.},
  author={Xiaochun Yu and K Devakanta Sharma and Tsuyoshi Takahashi and Ryo Iwamoto and Eisuke Mekada},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 7},
  pages={2547-57}
}
Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced signal transduction. However, the mechanism by which EGFR ligands induce dimerization and phosphorylation is not fully understood. Here, we demonstrate that EGFRs can form dimers on the cell surface independent of ligand binding. However, a chimeric receptor, comprising the extracellular and transmembrane domains of EGFR and the cytoplasmic domain of the… CONTINUE READING