Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation.

@article{Deblois2003LigandindependentCO,
  title={Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation.},
  author={Genevi{\`e}ve Deblois and Vincent Gigu{\`e}re},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2003},
  volume={85 2-5},
  pages={123-31}
}
Nuclear receptor coactivators are factors that enhance the transcriptional activity of the receptor. Coactivators usually work in ligand-independent and/or dependent manners by interacting with activation function-1 (AF-1) and AF-2 of the receptor, respectively. The recently characterized steroid receptor RNA activator (SRA) was cloned as an AF-1-dependent coactivator and shown to enhance the transcriptional activity of selected steroid receptors. In this work, we describe the effect of SRA on… CONTINUE READING