Ligand-gated ion channels: mechanisms underlying ion selectivity.

@article{Keramidas2004LigandgatedIC,
  title={Ligand-gated ion channels: mechanisms underlying ion selectivity.},
  author={Angelo Keramidas and Andrew J Moorhouse and Peter R. Schofield and Peter H. Barry},
  journal={Progress in biophysics and molecular biology},
  year={2004},
  volume={86 2},
  pages={
          161-204
        }
}
Anion/cation selectivity is a critical property of ion channels and underpins their physiological function. Recently, there have been numerous mutagenesis studies, which have mapped sites within the ion channel-forming segments of ligand-gated ion channels that are determinants of the ion selectivity. Site-directed mutations to specific amino acids within or flanking the M2 transmembrane segments of the anion-selective glycine, GABA(A) and GABA(C) receptors and the cation-selective nicotinic… CONTINUE READING

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