Ligand-free CuO nanospindle catalyzed arylation of heterocycle C-H bonds.


CuO nanospindles have been developed to efficiently catalyze the direct arylation of heterocycle C-H bonds with moderate to excellent yields. This reaction can be applied to heterocycles such as benzoxazole, benzothiazole, and 1-methylbenzimidazole in the presence of a more environmentally friendly inorganic base like K(2)CO(3) under ligand-free catalytic conditions. In addition, the catalyst can be recycled and reused without any significant decrease in catalytic activity.

DOI: 10.1021/jo200452x

Cite this paper

@article{Zhang2011LigandfreeCN, title={Ligand-free CuO nanospindle catalyzed arylation of heterocycle C-H bonds.}, author={Wu Zhang and Qinglong Zeng and Xinming Zhang and Yujie Tian and Y. Yue and Yujun Guo and Zhenghua Wang}, journal={The Journal of organic chemistry}, year={2011}, volume={76 11}, pages={4741-5} }