Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

@article{Hannum1994LigandFF,
  title={Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs},
  author={Charles Hannum and J Wesley Culpepper and Debbie Campbell and Terri Mcclanahan and Sandra Zurawski and Robert Kastelein and J. Fernando Bazan and Susan Hudak and John Wagner and Jeanine Mattson and Jeanne Luh and Georg Duda and Nathalie Martina and Denise Peterson and Satish Menon and Armen B. Shanafelt and M O Muench and G S Kelner and Reiko Namikawa and Donna M. Rennick and M.-G. Roncarolo and Albert Zlotnik and Olivier Rosnet and Patrice Dubreuil and Daniel Birnbaum and F O Lee},
  journal={Nature},
  year={1994},
  volume={368},
  pages={643-648}
}
THE FLT3/FLK2 receptor tyrosine kinase is closely related to two receptors, c-Kit and c-Fms, which function with their respective ligands, Kit ligand and macrophage colony-stimulating factor to control differentiation of haematopoietic and non-haematopoietic cells1–5. FLT3/FLK2 is thought to be present on haematopoietic stem cells and found in brain, placenta and testis3–5. We have purified to homogeneity and partially sequenced a soluble form of the FLT3/FLK2 ligand produced by mouse thymic… CONTINUE READING
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