Ligand-field and ligand-binding analysis of the active site of copper-bound Aβ associated with Alzheimer's disease.

@article{Ghosh2013LigandfieldAL,
  title={Ligand-field and ligand-binding analysis of the active site of copper-bound Aβ associated with Alzheimer's disease.},
  author={Chandradeep Ghosh and Somdatta Ghosh Dey},
  journal={Inorganic chemistry},
  year={2013},
  volume={52 3},
  pages={1318-27}
}
Alzheimer's disease (AD) patients show abnormally high concentrations of Cu(2+) in the amyloid β plaques. This invokes that Cu(2+) might play a crucial role in the onset of AD. The last few decades of research have also shown that Cu(2+) plays a significant role in the aggregation of Aβ plaques in the brain and the generation of oxidative stress. Because… CONTINUE READING