Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

@article{Pradhan2010LiganddirectedTO,
  title={Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.},
  author={Amynah Aa Pradhan and Wendy M Walwyn and Chihiro Nozaki and Dominique Filliol and Eric Erbs and Audrey Matifas and Christopher H. Evans and Brigitte Lina Kieffer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 49},
  pages={
          16459-68
        }
}
δ-Opioid receptors are G-protein-coupled receptors that regulate nociceptive and emotional responses. It has been well established that distinct agonists acting at the same G-protein-coupled receptor can engage different signaling or regulatory responses. This concept, known as biased agonism, has important biological and therapeutic implications. Ligand-biased responses are well described in cellular models, however, demonstrating the physiological relevance of biased agonism in vivo remains a… CONTINUE READING

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