Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

@article{Birtwistle2007LiganddependentRO,
  title={Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses},
  author={Marc R. Birtwistle and Mariko Hatakeyama and Noriko Yumoto and Babatunde A. Ogunnaike and Jan B. Hoek and Boris N. Kholodenko},
  journal={Molecular Systems Biology},
  year={2007},
  volume={3},
  pages={1147 - 1157}
}
Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB receptors with epidermal growth factor (EGF) and heregulin (HRG) leads to activation of two critical downstream proteins, extracellular-signal-regulated kinase (ERK) and Akt. Model analysis and experimental… CONTINUE READING
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