Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.

@article{Blobel1995LiganddependentRO,
  title={Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.},
  author={Gerd A Blobel and Colin A. Sieff and Stuart H Orkin},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 6},
  pages={3147-53}
}
High-dose estrogen administration induces anemia in mammals. In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation. This delay is associated with down-regulation of many erythroid cell-specific genes, including alpha- and beta-globin, band 3, band 4.1, and the erythroid cell-specific histone H5. We show here that estrogens also reduce the number of erythroid progenitor cells in primary human bone marrow cultures. To address… CONTINUE READING