Ligand-dependent inhibition of myoblast differentiation by overexpression of the type-1 insulin-like growth factor receptor.

Abstract

The insulin-like growth factors (IGFs) have paradoxical effects on skeletal myoblast differentiation. While low concentrations of IGF stimulate myoblast differentiation, high concentrations of IGF induce a progressive decrease in myoblast differentiation. The mechanism of this inhibition is unknown. Using a retroviral expression vector, we developed a… (More)

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