Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation.

@article{Wang2008LiganddependentIO,
  title={Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation.},
  author={Jianxiong Wang and Suzanne Cho and Aito Ueno and L O Cheng and B Xu and Melanie D. Desrosiers and Yan Shi and Yang Yang},
  journal={Journal of immunology},
  year={2008},
  volume={181 4},
  pages={2438-45}
}
Stimulated by an agonistic ligand, alpha-galactosylceramide (alphaGalCer), invariant NKT (iNKT) cells are capable of both eliciting antitumor responses and suppressing autoimmunity, while they become anergic after an initial phase of activation. It is unknown how iNKT cells act as either activators or regulators in different settings of cellular immunity. We examined effects of alphaGalCer administration on autoimmune inflammation and characterized phenotypes and functional status of iNKT cells… CONTINUE READING