Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.

@article{Tian2013LiganddependentCC,
  title={Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.},
  author={Xixi Tian and Yingjie Liu and Ying Yu Liu and Ruiwu Wang and Terence Wagenknecht and Zheng Liu and S R Wayne Chen},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 6},
  pages={4066-75}
}
Global conformational changes in the three-dimensional structure of the Ca(2+) release channel/ryanodine receptor (RyR) occur upon ligand activation. A number of ligands are able to activate the RyR channel, but whether these structurally diverse ligands induce the same or different conformational changes in the channel is largely unknown. Here we constructed a fluorescence resonance energy transfer (FRET)-based probe by inserting a CFP after residue Ser-2367 and a YFP after residue Tyr-2801 in… CONTINUE READING

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