Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.

@article{Pham1992LiganddependentA,
  title={Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.},
  author={Thinh A. Pham and Y P Hwung and Dolores Santiso-Mere and Donald P McDonnell and Bert W O'Malley},
  journal={Molecular endocrinology},
  year={1992},
  volume={6 7},
  pages={
          1043-50
        }
}
The estrogen receptor (ER) is a transcription factor involved in steroid hormone signal transduction in higher eukaryotes. The receptor also functions as a ligand-dependent transcriptional activator when introduced into Saccharomyces cerevisiae (baker's yeast), which suggests that at least some of the components of the signal transduction pathway are conserved between yeast and mammalian cells, and, moreover, allows the possibility of using this simple eukaryotic organism to dissect receptor… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Similar Papers

Loading similar papers…