Ligand-dependent G protein coupling function of amyloid transmembrane precursor.

@article{Okamoto1995LiganddependentGP,
  title={Ligand-dependent G protein coupling function of amyloid transmembrane precursor.},
  author={Tomomitsu Okamoto and Sayako Takeda and Yoshihiro Murayama and Etsuro Ogata and Ikuo Nishimoto},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 9},
  pages={
          4205-8
        }
}
Amyloid precursor protein (APP), a transmembrane precursor of beta-amyloid, possesses a function whereby it associates with G(o) through its cytoplasmic His657-Lys676. Here we demonstrate that APP has a receptor function. In phospholipid vesicles consisting of baculovirally made APP695 and brain trimeric G(o), 22C11, a monoclonal antibody against the extracellular domain of APP, increased GTP gamma S binding and the turnover number of GTPase of G(o) without affecting its intrinsic GTPase… CONTINUE READING

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