Ligand binding to Fc gamma R induces c-myc-dependent apoptosis in IL-2-stimulated NK cells.

@article{Azzoni1995LigandBT,
  title={Ligand binding to Fc gamma R induces c-myc-dependent apoptosis in IL-2-stimulated NK cells.},
  author={Livio Azzoni and Ignacio Anegon and Bruno Calabretta and Bice Perussia},
  journal={Journal of immunology},
  year={1995},
  volume={154 2},
  pages={491-9}
}
The role of signals transduced via Fc gamma RIIIA in the modulation of the proliferative potential of NK cells has been investigated. Fc gamma R stimulation does not induce NK cell proliferation, and inhibits that induced by IL-2, but not by IL-12, as measured by [3H]TdR incorporation, without affecting entrance or progression through cell cycle. The inhibitory effect depends, at least in part, on induced apoptosis of the cells, detected by both light and electron microscopy examination. Fc… CONTINUE READING

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