Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1.

@article{Dougherty1994LigandBS,
  title={Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1.},
  author={Graeme J. Dougherty and David L. Cooper and J F Memory and Roland K. Chiu},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 12},
  pages={9074-8}
}
CD44 species of widely differing molecular mass have been identified on various normal and/or transformed cells. Recent studies have demonstrated that much of this heterogeneity is produced as a result of the alternative splicing of a series of 10 exons present within the CD44 gene generating a large number of CD44 isoforms containing additional peptide sequences of varying length inserted into a single site within the extracellular domain of the molecule. At present, the effect of such… CONTINUE READING

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