Ligand binding regulates the directed movement of β1 integrins on fibroblasts

@article{Felsenfeld1996LigandBR,
  title={Ligand binding regulates the directed movement of β1 integrins on fibroblasts},
  author={Dan Felsenfeld and Daniel Choquet and Michael P Sheetz},
  journal={Nature},
  year={1996},
  volume={383},
  pages={438-440}
}
TO enable cells to crawl, adhesion receptors such as integrins must bind to extracellular molecules and simultaneously interact with force-generating components of the cytoskeleton1,2. We show here that the binding of extracellular ligand in living cells induces the attachment of β1 integrins to the retrograde-moving cytoskeleton. Unliganded integrins are… CONTINUE READING