Ligand binding regions in the receptor for urokinase-type plasminogen activator.

@article{Liang2001LigandBR,
  title={Ligand binding regions in the receptor for urokinase-type plasminogen activator.},
  author={Olin D. Liang and Triantafyllos Chavakis and Sandip M Kanse and Klaus Theo Preissner},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 31},
  pages={28946-53}
}
The interaction between urokinase plasminogen activator (uPA) and its cellular receptor (uPAR) is a key event in cell surface-associated plasminogen activation, relevant for cell migration and invasion. In order to define receptor recognition sites for uPA, we have expressed uPAR fragments as fusion products with the minor coat protein on the surface of M13 bacteriophages. Sequence analysis of cDNA fragments encoding uPA-binding peptides indicated the existence of a composite uPA-binding… CONTINUE READING