Ligand binding profile of the rat metabotropic glutamate receptor mGluR3 expressed in a transfected cell line

Abstract

A cDNA clone encoding the rat metabotropic glutamate receptor mGluR3 was stably transfected into human embryonic kidney 293 cells. Receptor-expressing cell lines were characterized by centrifugation binding assays using [3H]glutamate as radioligand. The rank order of affinity was l-glutamate>(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)>L… (More)
DOI: 10.1007/BF00171050

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