Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis.

Abstract

CD46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens, including the measles virus and human herpes virus 6. Ligand binding to CD46 affects (i) protection of autologous cells from complement attack by breakdown of complement components, (ii) intracellular signals that affect the regulation of… (More)

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