Ligand-binding and signaling properties of the Ax[M1] form of Notch

  title={Ligand-binding and signaling properties of the Ax[M1] form of Notch},
  author={Lidia Mart{\'i}nez P{\'e}rez and Marco Mil{\'a}n and Sarah Bray and Stephen Michael Cohen},
  journal={Mechanisms of Development},
The Abruptex class of Notch alleles has attracted interest because they exhibit some properties that are best explained in terms of increased activity and others that are best explained in terms of reduced activity in vivo. Here, we report a comparison of the properties of Abruptex[M1] and wild-type Notch as ligand binding receptors. Abruptex[M1] showed less activity than wild-type Notch in its ability to bind Delta and Serrate and was expressed at reduced levels on the cell surface. When… CONTINUE READING

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Dorsal and ventral cells respond differently to the Notch ligands Delta and Serrate during Drosophila wing development

  • D. Doherty, G. Fenger, S. Younger-Shepherd, Jan, L.-Y, Y.-N
  • Genes Dev
  • 1996
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