Ligand binding and nuclear receptor evolution.

@article{Escriv2000LigandBA,
  title={Ligand binding and nuclear receptor evolution.},
  author={H{\'e}ctor Escriv{\`a} and Franck Delaunay and Vincent Laudet},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2000},
  volume={22 8},
  pages={717-27}
}
Nuclear receptors form a superfamily of ligand-activated transcription factors that regulate various physiological functions, from development to homeostasis, in metazoans. The superfamily contains not only receptors for known ligands but also a large number of so-called orphan receptors for which ligands do not exist or have not been identified. The evolution of ligand-binding capacity of nuclear receptors may involve either secondary loss in orphan receptors, or evolutionary acquisition of… CONTINUE READING

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