Ligand binding and activation of the CGRP receptor.

  title={Ligand binding and activation of the CGRP receptor.},
  author={Alex C Conner and John Simms and James Barwell and Mark Wheatley and David R Poyner},
  journal={Biochemical Society transactions},
  volume={35 Pt 4},
The receptor for CGRP (calcitonin gene-related peptide) is a heterodimer between a GPCR (G-protein-coupled receptor), CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity-modifying protein 1). Models have been produced of RAMP1 and CLR. It is likely that the C-terminus of CGRP interacts with the extracellular N-termini of CLR and RAMP1; the extreme N-terminus of CLR is particularly important and may interact directly with CGRP and also with RAMP1. The N… CONTINUE READING