Ligand-based virtual screening to identify new T-type calcium channel blockers.

@article{Ijjaali2007LigandbasedVS,
  title={Ligand-based virtual screening to identify new T-type calcium channel blockers.},
  author={Isma{\"i}l Ijjaali and Christian Barr{\`e}re and Joel Nargeot and François Petitet and Emmanuel Bourinet},
  journal={Channels},
  year={2007},
  volume={1 4},
  pages={300-4}
}
T-type calcium channels are involved in the generation of rhythmical firing patterns in the mammalian central nervous system and in various pathological alterations of neuronal excitability such as in epilepsy or neuropathic pain. In the search for new T-type calcium channel blockers that would help to treat these disorders, we have followed a bi-dimensional pharmacophore-based virtual screening approach to identify new inhibitors. Nineteen molecules extracted from AurSCOPE Ion Channels… CONTINUE READING