Ligand and substrate effects during Pd-catalyzed cyclizations of alkyne-tethered cyclohexadienones.

@article{TelloAburto2013LigandAS,
  title={Ligand and substrate effects during Pd-catalyzed cyclizations of alkyne-tethered cyclohexadienones.},
  author={Rodolfo Tello-Aburto and Kyle A. Kalstabakken and Andrew M Harned},
  journal={Organic \& biomolecular chemistry},
  year={2013},
  volume={11 34},
  pages={
          5596-604
        }
}
The effects of ligand and substrate choice on the Pd-catalyzed cyclization of alkyne-tethered cyclohexadienones were examined. In the presence of a chiral ligand, the enantioselectivity of the desymmetrization is remarkably sensitive to structural changes in both the ligand and the substrate. Additionally, the regioselectivity of the reaction (5- vs. 6-membered ring formation) is dependent on the proximity of heteroatoms to the alkyne. 
30 Citations
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