Ligand and antagonist driven regulation of the Vibrio cholerae quorum-sensing receptor CqsS

Abstract

Quorum sensing, a bacterial cell-cell communication process, controls biofilm formation and virulence factor production in Vibrio cholerae, a human pathogen that causes the disease cholera. The major V. cholerae autoinducer is (S)-3-hydroxytridecan-4-one (CAI-1). A membrane bound two-component sensor histidine kinase called CqsS detects CAI-1, and the CqsS… (More)
DOI: 10.1111/j.1365-2958.2012.07992.x

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