Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3

@inproceedings{Degnin2011LigandAL,
  title={Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3},
  author={Catherine R. Degnin and Melanie B. Laederich and William A Horton},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Fibroblast growth factor receptor 3 (FGFR3) is a major negative regulator of bone growth that inhibits the proliferation and differentiation of growth plate chondrocytes. Activating mutations of its c isoform cause dwarfism in humans; somatic mutations can drive oncogenic transformation in multiple myeloma and bladder cancer. How these distinct activities arise is not clear. FGFR3 was previously shown to undergo proteolytic cleavage in the bovine rib growth plate, but this was not explored… CONTINUE READING
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