Ligand-activated signal transduction in the 2-cell embryo.

  title={Ligand-activated signal transduction in the 2-cell embryo.},
  author={David P Lu and Yan Li and Roslyn Bathgate and Margot Day and Christopher O'Neill},
  journal={Biology of reproduction},
  volume={69 1},
Platelet-activating factor (PAF) is an autocrine trophic/survival factor for the preimplantation embryo. PAF induced an increase in intracellular calcium concentration ([Ca2+]i) in the 2-cell embryo that had an absolute requirement for external calcium. L-type calcium channel blockers (diltiazem, verapamil, and nimodipine) significantly inhibited PAF-induced Ca2+ transients, but inhibitors of P/Q type (omega-agatoxin; omega-conotoxin MVIIC), N-type (omega-conotoxin GVIA), T-type (pimozide), and… CONTINUE READING


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Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro

  • C. O’Neill
  • Biology of Reproduction
  • 1997
Highly Influential
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