Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells.

@article{Tang2005LigandAR,
  title={Ligand activated relaxin receptor increases the transcription of IGFBP-1 and prolactin in human decidual and endometrial stromal cells.},
  author={Meiyi Tang and James Mazella and Hui Hui Zhu and Linda Tzu-Ling Tseng},
  journal={Molecular human reproduction},
  year={2005},
  volume={11 4},
  pages={237-43}
}
The aim of this study was to investigate relaxin (RLX) receptor-mediated gene activation in human endometrium. We determined the promoter activities of insulin-like growth factor binding protein-1 (IGFBP-1) and prolactin (PRL) and identified sequence(s) that mediate RLX activated transcription in human decidual cells and endometrial stromal cells. In human decidual cells, the promoter activity of IGFBP-1 was increased significantly in cells incubated with RLX. In endometrial stromal cells, the… CONTINUE READING

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