Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.

@article{Schaiff2007LigandactivatedPP,
  title={Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice.},
  author={W Timothy Schaiff and Furn F Russ Knapp and Yaacov Barak and Tal Biron-Shental and David M. Q. Nelson and Yoel Sadovsky},
  journal={Endocrinology},
  year={2007},
  volume={148 8},
  pages={3625-34}
}
The nuclear receptor peroxisome proliferator activated receptor gamma (PPARgamma) is essential for murine placental development. We previously showed that activation of PPARgamma in primary human trophoblasts enhances the uptake of fatty acids and alters the expression of several proteins associated with fatty acid trafficking. In this study we examined the effect of ligand-activated PPARgamma on placental development and transplacental fatty acid transport in wild-type (wt) and PPARgamma… CONTINUE READING

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