Ligand activated hPR modulates the glycodelin promoter activity through the Sp1 sites in human endometrial adenocarcinoma cells.

@article{Gao2001LigandAH,
  title={Ligand activated hPR modulates the glycodelin promoter activity through the Sp1 sites in human endometrial adenocarcinoma cells.},
  author={Jiaguo Gao and James Mazella and Markku Seppala and Linda Tzu-Ling Tseng},
  journal={Molecular and cellular endocrinology},
  year={2001},
  volume={176 1-2},
  pages={97-102}
}
Human endometrium produces glycodelin-A (GdA). The GdA mRNA is highly expressed in progestin-sensitized human endometrial glandular epithelial cells. The mechanism of GdA gene expression, however, is not clear. To understand the cell specific GdA gene transcription, our first approach was to identify the cis-element in the GdA promoter using transfection assay in a human endometrial adenocarcinoma cell line (HEC-1B, a cell line originally derived from the glandular component of the endometrium… CONTINUE READING