Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production.

@article{Ham2012LigandactivatedPI,
  title={Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production.},
  author={Sun Ah Ham and Jung Seok Hwang and Taesik Yoo and Hanna Lee and Eun Sil Kang and Chankyu Park and J Oh and Hoon Taek Lee and Gyesik Min and Jin-Hoi Kim and Han Geuk Seo},
  journal={The Biochemical journal},
  year={2012},
  volume={444 1},
  pages={27-38}
}
UV radiation-mediated photodamage to the skin has been implicated in premature aging and photoaging-related skin cancer and melanoma. Little is known about the cellular events that underlie premature senescence, or how to impede these events. In the present study we demonstrate that PPARδ (peroxisome-proliferator-activated receptor δ) regulates UVB-induced premature senescence of normal keratinocytes. Activation of PPARδ by GW501516, a specific ligand of PPARδ, significantly attenuated UVB… CONTINUE READING
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