Ligand-Targeted Drug Delivery.

@article{Srinivasarao2017LigandTargetedDD,
  title={Ligand-Targeted Drug Delivery.},
  author={M. Srinivasarao and P. Low},
  journal={Chemical reviews},
  year={2017},
  volume={117 19},
  pages={
          12133-12164
        }
}
  • M. Srinivasarao, P. Low
  • Published 2017
  • Chemistry, Medicine
  • Chemical reviews
  • Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic agent with a targeting ligand that exhibits little affinity for healthy cells but high affinity for pathologic cells. The probability of regulatory approval can conceivably be further enhanced by exploiting the same targeting ligand, conjugated to an imaging agent, to select patients whose diseased tissues display… CONTINUE READING
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