Ligand Exchange Reactions of Gold Drugs in Model Systems and in Red Cells

@inproceedings{Razi1983LigandER,
  title={Ligand Exchange Reactions of Gold Drugs in Model Systems and in Red Cells},
  author={Muhammad Tahir Razi and Gabriel Otiko and Peter J. Sadler},
  year={1983}
}
17 Citations
Progress in the characterization of gold drugs
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NMR methods are used to examine in vitro the partition of auranofin between plasma and blood cells and the displacement of the thioglucose ligand and release of PEt3 from gold as OPEt3 are discussed.
Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase.
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The gold(i) thiourea complex exhibits a potent tight-binding inhibition of the anticancer drug target thioredoxin reductase with an inhibitory constant at nanomolar level.
NMR and ESR Spectroscopy Applied to Gold and Silver Compounds
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The effect of gold ligation on the inhibition of bovine erythrocyte selenium-glutathione peroxidase (GSH-Px) was examined and confirmed the previous postulate that Au(SG)2- is generated from AuSTg in the presence of excess glutathione.
1H,13C-NMR and X-ray absorption studies of copper(I) glutathione complexes.
TLDR
The high thermodynamic stability of Cu(I)-S bonds in Cu (I)-glutathione complexes coupled with their kinetic lability may provide efficient and specific pathways for the transport of copper in cells.
Inorganic Chemistry and Drug Design
Publisher Summary This chapter discusses some of the current uses of inorganic compounds as drugs and diagnostic agents. It focuses on areas of demonstrated medical and clinical interest. The
Control of oxidative damage in rheumatoid arthritis by gold(I)-thiolate drugs.
The roles of anti-arthritic gold(I)-thiolate drugs such as disodium aurothiomalate ('Myocrisin') in the modulation or promotion of oxygen radical-mediated oxidative damage in vivo are reviewed. In
Gold(I) efflux from auranofin-treated red blood cells. Evidence for a glutathione-gold-albumin metabolite.
TLDR
Glutathione, generated by in situ labeling, also effluxed and associated with the albumin and gold, providing the first direct evidence that the album in-gold-glutathion complex (AlbSAuSG) may be a circulating metabolite of auranofin formed after both of the original ligands of aurenofin are displaced.
Metal Complexes in Arthritis
TLDR
Rheumatoid arthritis is a chronic inflammatory disease of unknown causation, manifested particularly in the peripheral joints, and disordered immune responses are most likely to be involved in initiation of the disease.
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