Ligand-Dependent Opening of the Multiple AMPA Receptor Conductance States: A Concerted Model

  title={Ligand-Dependent Opening of the Multiple AMPA Receptor Conductance States: A Concerted Model},
  author={Ranjita Dutta-Roy and Christian Rosenmund and Stuart J. Edelstein and Nicolas Gambardella Le Nov{\`e}re},
  journal={PLoS ONE},
Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms underlying fast synaptic transmission in the central nervous system of vertebrates. Electrophysiological recordings of single channels stimulated with agonists showed that both recombinant and native AMPA receptors visit multiple conductance states in an agonist concentration dependent manner. We propose an allosteric model of the multiple conductance states based on concerted… 

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