Ligand Binding and Structural Analysis of a Human Putative Cellular Retinol-binding Protein*

@article{Folli2002LigandBA,
  title={Ligand Binding and Structural Analysis of a Human Putative Cellular Retinol-binding Protein*},
  author={C. Folli and V. Calderone and Ileana Ramazzina and G. Zanotti and R. Berni},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={41970 - 41977}
}
Three cellular retinol-binding protein (CRBP) types (CRBP I, II, and III) with distinct tissue distributions and retinoid binding properties have been structurally characterized thus far. A human binding protein, whose mRNA is expressed primarily in kidney, heart, and transverse colon, is shown here to be a CRBP family member (human CRBP IV), according to amino acid sequence, phylogenetic analysis, gene structure organization, and x-ray structural analysis. Retinol binding to CRBP IV leads to… Expand
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