Ligand Binding Sites of Inducible Costimulator and High Avidity Mutants with Improved Function

Abstract

Interaction between inducible costimulator (ICOS) and its ligand is implicated in the induction of cell-mediated and humoral immune responses. However, the molecular details of this interaction are unknown. We report here a mutagenesis analysis of residues in ICOS that are critical for ligand binding. A three-dimensional model of the extracellular… (More)

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