Ligand Based Virtual Screening to Identify Potential Anti Cancer Ligands Similar to Withaferin A Targeting Indoleamine 2,3-Dioxygenase

@article{Reddy2014LigandBV,
  title={Ligand Based Virtual Screening to Identify Potential Anti Cancer Ligands Similar to Withaferin A Targeting Indoleamine 2,3-Dioxygenase},
  author={S. Reddy and K. T. Reddy and V. Kumari},
  journal={Biosciences, Biotechnology Research Asia},
  year={2014},
  volume={11},
  pages={887-893}
}
For the treatment of cancer, Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic drug target characterized by pathological immune suppression. On the other hand, Withaferin A (WA) – active constituent of Withania somnifera ayurvedic herb has shown to be having a wide range of targeted anti cancer properties. Previously, we have elucidated the potential of WA in attenuating the Indoleamine 2,3-dioxygenase for immunotherapeutic tumor arresting activity using… Expand

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References

SHOWING 1-10 OF 10 REFERENCES
ZINC - A Free Database of Commercially Available Compounds for Virtual Screening
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase.
The Protein Data Bank: a computer-based archival file for macromolecular structures.
The Protein Data Bank. A computer-based archival file for macromolecular structures.
Genetic regulation of cancer
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