Ligand-Based Virtual Screening Approach Using a New Scoring Function

  title={Ligand-Based Virtual Screening Approach Using a New Scoring Function},
  author={Adel Hamza and Ning-Ning Wei and Chang-Guo Zhan},
  journal={Journal of chemical information and modeling},
  volume={52 4},
In this study, we aimed to develop a new ligand-based virtual screening approach using an effective shape-overlapping procedure and a more robust scoring function (denoted by the HWZ score for convenience). The HWZ score-based virtual screening approach was tested against the compounds for 40 protein targets available in the Database of Useful Decoys (DUD; ), and the virtual screening performance was evaluated in terms of the area under the receiver operator characteristic… CONTINUE READING


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